ABSTRACT
Objective To investigate the effect of Shenmai injection on cytokines and ESAT-6/CFP-10 levels in patients with Chronic obstructive pulmonary disease(COPD)with pulmonary tuberculosis.Methods158 patients with COPD with pulmonary tuberculosis from the Department of Respiratory in our hospital were selected and divided into 2 groups, 79 cases in the control group treated with routine treatment, 79 cases in the experiment group treated with Shenmai injection on the basis of the control group, levels of neurotransmitters in the brain, serum ESAT-6 protein, CFP-10 protein, IFN-γ levels, cytokine levels, peripheral blood immune cell levels, and the clinical effect and the focus absorption efficiency were compared after the treatment.ResultsThe clinical total effective rate in the control group(84.81%)was lower than that in the experiment group(94.94%), with significant difference (P<0.05);the focus absorption efficiency in the control group(87.33%)was lower than that in the experiment group(96.21%), with significant difference (P<0.05);compared with the control group, serum ESAT-6 protein、 CFP-10 protein、IFN-γ levels were lower after treatment in the experiment group, the serum levels of TNF-α、IL-6、sIL-2R were lower, peripheral blood levels of NK cells, CD4+T lymphocytes and CD4+/CD8+ were higher, peripheral blood level of CD8+T lymphocytes was lower, with significant difference (P<0.05).ConclusionShenmai injection can significantly reduce the serum levels of TNF-α、IL-6、sIL-2R and ESAT-6/CFP-10 in patients with COPD with pulmonary tuberculosis, improve cellular immune function, promote the absorption of lesions effectively,and improve clinical efficacy.
ABSTRACT
Objective To investigate the effect of Shenmai injection combined with noninvasive ventilator on MDA , SOD and clinical efficacy in treatment of elderly patients with chronic respiratory failure.Methods 72 cases of elderly patients with chronic respiratory failure were randomly divided into control group and experimental group.Control group of 35 patients were treated with conventional therapy and the treatment of noninvasive ventilator, experimental group of 37 patients were treated combined with Shenmai injection for 1 weeks.The level of serum MDA, SOD and clinical efficacy were compared.Results The serum MDA level was decreased, SOD level increased in 2 groups after treatment (P<0.05), the level of MDA in experimental group was lower than control group, and the level of SOD was higher (P<0.05).The level of PaO2 was increased, PaCO2 level and QOL score decreased,the level of PaO2 in experimental group was higher than control group, the QOL score was lower than that of control group ( P<0.05),and there was no difference in PaCO2.After treatment, the total effective rate of experimental group was significantly higher than control group (P<0.05).Conclusion Shenmai injection combined noninvasive ventilator is effective on elderly patients with chronic respiratory failure, it can reduce serum MDA level, increase the serum SOD level.